Synonym
HUP-28; HUP 28; HUP28
IUPAC/Chemical Name
N-((S)-1-((S)-2-(4H-1,2,4-triazol-3-yl)pyrrolidin-1-yl)-1-oxopropan-2-yl)-4-phenylbutanamide
InChi Key
OKJLZDISZCWKJW-HOCLYGCPSA-N
InChi Code
InChI=1S/C19H25N5O2/c1-14(22-17(25)11-5-9-15-7-3-2-4-8-15)19(26)24-12-6-10-16(24)18-20-13-21-23-18/h2-4,7-8,13-14,16H,5-6,9-12H2,1H3,(H,22,25)(H,20,21,23)/t14-,16-/m0/s1
SMILES Code
C[C@@H](C(N1[C@H](C2=NN=CN2)CCC1)=O)NC(CCCC3=CC=CC=C3)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
355.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
TY - JOUR
T1 - 5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
AU - Pätsi, Henri T.
AU - Kilpeläinen, Tommi P.
AU - Jumppanen, Mikael
AU - Uhari-Väänänen, Johanna
AU - Wielendaele, Pieter Van
AU - De Lorenzo, Francesca
AU - Cui, Hengjing
AU - Auno, Samuli
AU - Saharinen, Janne
AU - Seppälä, Erin
AU - Sipari, Nina
AU - Savinainen, Juha
AU - De Meester, Ingrid
AU - Lambeir, Anne-Marie
AU - Lahtela-Kakkonen, Maija
AU - Myöhänen, Timo T.
AU - Wallén, Erik A. A.
Y1 - 2024/03/28
PY - 2024
DA - 2024/03/28
N1 - doi: 10.1021/acs.jmedchem.3c01993
DO - 10.1021/acs.jmedchem.3c01993
T2 - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
JO - J. Med. Chem.
PB - American Chemical Society
SN - 0022-2623
M3 - doi: 10.1021/acs.jmedchem.3c01993
UR - https://doi.org/10.1021/acs.jmedchem.3c01993
ER -
