CRN04894 is a highly potent and subtype-selective first-in-class MC2R antagonist (hMC2R KB = 0.34 nM; rMC2R KB = 0.23 nM), which demonstrated remarkable efficacy in a rat model of adrenocorticotrophic hormone (ACTH)-stimulated corticosterone secretion. Oral administration of CRN04894 suppressed ACTH-stimulated corticosterone secretion in a dose-dependent manner at doses ≥3 mg/kg.
MedKoo Cat#: 126563
Name: CRN04894
CAS#: N/A
Chemical Formula: C33H42F3N5O3
Exact Mass: 613.3240
Molecular Weight: 613.73
Elemental Analysis: C, 64.58; H, 6.90; F, 9.29; N, 11.41; O, 7.82
The following data is based on the product molecular weight 613.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
