Segatroxaban | A dual Xa/IIa inhibitor | CAS#1184300-63-7

MedKoo Cat#: 126555 | Name: Segatroxaban

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Segatroxaban is a blood coagulation factors Xa and IIa (thrombin) inhibitor.

Chemical Structure

Segatroxaban

CAS#1184300-63-7

Theoretical Analysis

MedKoo Cat#: 126555

Name: Segatroxaban

CAS#: 1184300-63-7

Chemical Formula: C24H30ClN5O5S2

Exact Mass: 567.1377

Molecular Weight: 568.10

Elemental Analysis: C, 50.74; H, 5.32; Cl, 6.24; N, 12.33; O, 14.08; S, 11.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

segatroxabanum; segatroxaban; SAR107375E

IUPAC/Chemical Name

(S)-5-chloro-N-(2-((2-methyl-3-(2-oxopyrrolidin-1-yl)phenyl)sulfonamido)-3-(4-methylpiperazin-1-yl)-3-oxopropyl)thiophene-2-carboxamide

InChi Key

CYVVCTRDWISRAC-KRWDZBQOSA-N

InChi Code

InChI=1S/C24H30ClN5O5S2/c1-16-18(30-10-4-7-22(30)31)5-3-6-20(16)37(34,35)27-17(24(33)29-13-11-28(2)12-14-29)15-26-23(32)19-8-9-21(25)36-19/h3,5-6,8-9,17,27H,4,7,10-15H2,1-2H3,(H,26,32)/t17-/m0/s1

SMILES Code

ClC1=CC=C(C(NC[C@@](NS(C2=C(C)C(N3CCCC3=O)=CC=C2)(=O)=O)([H])C(N4CCN(C)CC4)=O)=O)S1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 568.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Wu S, Wang T, Li J, Zhang Z, Li C, Xiao S, He J, Wang X, Hu Z, Wang X, Zheng S, Liang X, Chen G, Li Y, Li X, Zhan Y, Zou Q, Jiang H, Zheng Q, Ban L, Liu H, Fang Y. First-in-human trial of SAR107375E, a novel small molecule anticoagulant with dual inhibition of factor Xa and factor IIa. Expert Opin Investig Drugs. 2023 Jul-Dec;32(11):1085-1094. doi: 10.1080/13543784.2023.2283024. Epub 2023 Nov 24. PMID: 37955047.