CT1-3 is a magnolol-sulforaphane (MAG-SFN) hybrid . It showed more efficient anticancer activity than its lead compounds MAG and SFN with IC50 values ranging from 5.10 to 14.06 μM in multiple cancer cells. CT1-3 elicited a strong antitumor effect in vivo but has no hepatic and renal toxicity. CT1-3 treatment resulted in reduction of Bcl-2 and XIAP levels, in addition to increase of phospho-JNK and Bax levels, leading to mitochondria-mediated apoptosis in human cancer cells. CT1-3 could reduce the capacity of migration and invasion of human cancer cells via regulating the E-cadherin/Snail axis.
MedKoo Cat#: 126532
Name: CT1-3
CAS#: 2460738-32-1
Chemical Formula: C25H29NO3S2
Exact Mass: 455.1589
Molecular Weight: 455.63
Elemental Analysis: C, 65.90; H, 6.42; N, 3.07; O, 10.53; S, 14.07
The following data is based on the product molecular weight 455.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
