BIO-7488 is a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor (IC50 = 0.6 nM)for the Treatment of Ischemic Stroke. Interleukin receptor-associated kinase 4 (IRAK4) is a key node of signaling within the innate immune system that regulates the production of inflammatory cytokines and chemokines. The presence of damage-associated molecular patterns (DAMPs) after tissue damage such as stroke or traumatic brain injury (TBI) initiates signaling through the IRAK4 pathway that can lead to a feed-forward inflammatory loop that can ultimately hinder patient recovery.
MedKoo Cat#: 126507
Name: BIO-7488
CAS#: N/A
Chemical Formula: C23H25N7O3
Exact Mass: 447.2019
Molecular Weight: 447.50
Elemental Analysis: C, 61.73; H, 5.63; N, 21.91; O, 10.73
The following data is based on the product molecular weight 447.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
