Enzomenib, also known as DSP-5336, is a potetn and orally active menin inhibitor. DSP-5336 targets and binds to the nuclear protein menin, thereby preventing the interaction between the two proteins menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells.
MedKoo Cat#: 126504
Name: Enzomenib
CAS#: 2412555-70-3
Chemical Formula: C33H43FN6O3
Exact Mass: 590.3381
Molecular Weight: 590.74
Elemental Analysis: C, 67.10; H, 7.34; F, 3.22; N, 14.23; O, 8.12
The following data is based on the product molecular weight 590.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
