ZX703 is a GPX4 degrader which induces Ferroptosis in Human Cancer Cells (DC50 = 0.135 uM in HT1080). ZX703 significantly degraded GPX4 through the ubiquitin−proteasome and the autophagy−lysosome pathways in a dose- and time-dependent manner. Moreover, ZX703 was found to induce the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells, thereby inducing ferroptosis.
MedKoo Cat#: 126325
Name: ZX703
CAS#: N/A
Chemical Formula: C54H67ClN8O9S
Exact Mass: 1038.4440
Molecular Weight: 1039.69
Elemental Analysis: C, 62.38; H, 6.50; Cl, 3.41; N, 10.78; O, 13.85; S, 3.08
The following data is based on the product molecular weight 1,039.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
