CMX990 is a SARS-CoV-2 3CLpro inhibitor (IC50 = 23.4 nM), CMX990, bearing an unprecedented trifluoromethoxymethyl ketone warhead. Compared with the marketed drug nirmatrelvir (combination with ritonavir = Paxlovid), CMX990 has distinctly differentiated potency (∼5× more potent in primary cells) and human in vitro clearance (>4× better microsomal clearance and >10× better hepatocyte clearance), with good in vitro-to-in vivo correlation.
MedKoo Cat#: 126324
Name: CMX990
CAS#: 2882934-64-5
Chemical Formula: C22H32F3N3O6
Exact Mass: 491.2243
Molecular Weight: 491.51
Elemental Analysis: C, 53.76; H, 6.56; F, 11.60; N, 8.55; O, 19.53
The following data is based on the product molecular weight 491.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
