QC-182 is a PROTAC Degrader of p300/CBP as potential therapeutics for hepatocellular carcinoma (DC50 = 93 nM). QC-182 effectively induces p300/CBP degradation in the SK-HEP-1 HCC cells in a dose-, time-, and ubiquitin-proteasome system-dependent manner. QC-182 significantly downregulates p300/CBP-associated transcriptome in HCC cells, leading to more potent cell growth inhibition compared to the parental inhibitors and the reported degrader dCBP-1. Notably, QC-182 potently depletes p300/CBP proteins in mouse SK-HEP-1 xenograft tumor tissue.
MedKoo Cat#: 126157
Name: QC-182
CAS#: N/A
Chemical Formula: C44H42F2N8O6
Exact Mass: 816.3195
Molecular Weight: 816.87
Elemental Analysis: C, 64.70; H, 5.18; F, 4.65; N, 13.72; O, 11.75
The following data is based on the product molecular weight 816.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
