Caspase-1 Inhibitor IV | Caspase-1 | CAS#154674-81-4

MedKoo Cat#: 126118 | Name: Caspase-1 Inhibitor IV

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Caspase-1 Inhibitor IV controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Chemical Structure

Caspase-1 Inhibitor IV

CAS#154674-81-4

Theoretical Analysis

MedKoo Cat#: 126118

Name: Caspase-1 Inhibitor IV

CAS#: 154674-81-4

Chemical Formula: C33H42N4O10

Exact Mass: 654.2901

Molecular Weight: 654.72

Elemental Analysis: C, 60.54; H, 6.47; N, 8.56; O, 24.44

Price and Availability

Size	Price	Availability
10mg	USD 1,250.00	2 Weeks
25mg	USD 1,950.00	2 Weeks
50mg	USD 2,950.00	2 Weeks
100mg	USD 4,250.00	2 Weeks

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Related CAS #

No Data

Synonym

Ac-YVAD-AOM; Caspase-1 Inhibitor IV; Caspase1 Inhibitor-IV; Caspase-1-Inhibitor-IV

IUPAC/Chemical Name

(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-(2,6-dimethylbenzoyl)oxy-4-oxopentanoic acid

InChi Key

LOACDHZQOPEFKK-NFJAKAEBSA-N

InChi Code

InChI=1S/C33H42N4O10/c1-17(2)29(37-31(44)25(35-21(6)38)14-22-10-12-23(39)13-11-22)32(45)34-20(5)30(43)36-24(15-27(41)42)26(40)16-47-33(46)28-18(3)8-7-9-19(28)4/h7-13,17,20,24-25,29,39H,14-16H2,1-6H3,(H,34,45)(H,35,38)(H,36,43)(H,37,44)(H,41,42)/t20-,24-,25-,29-/m0/s1

SMILES Code

O=C(O)C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)C(C)C)=O)C)=O)C(COC(C2=C(C)C=CC=C2C)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 654.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Su XL, Wang SH, Komal S, Cui LG, Ni RC, Zhang LR, Han SN. The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway. Acta Pharmacol Sin. 2022 Sep;43(9):2289-2301. doi: 10.1038/s41401-021-00845-8. Epub 2022 Feb 7. PMID: 35132192; PMCID: PMC9433445. 2: Mathiak G, Grass G, Herzmann T, Luebke T, Zetina CC, Boehm SA, Bohlen H, Neville LF, Hoelscher AH. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000 Oct;131(3):383-6. doi: 10.1038/sj.bjp.0703629. PMID: 11015286; PMCID: PMC1572369.