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MedKoo Cat#: 126115 | Name: Clovibactin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clovibactin (Novo29) is an experimental antibiotic isolated from an uncultured soil Gram-negative β-proteobacterium Eleftheria terrae ssp. carolina, which is one of many soil bacteria.

Chemical Structure

Clovibactin
Clovibactin
CAS#2247194-77-8

Theoretical Analysis

MedKoo Cat#: 126115

Name: Clovibactin

CAS#: 2247194-77-8

Chemical Formula:

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clovibactin; Novo29; Novo 29; Novo-29;
IUPAC/Chemical Name
(3S,6S,9S,13R)-12-[[(2S)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-9-methyl-3,6-bis(2-methylpropyl)-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecane-13-carboxamide
InChi Key
SMQAHGKBWXPEHB-MJGFNNBQSA-N
InChi Code
InChI=1S/C43H70N10O11/c1-22(2)17-29-40(60)51-31(19-24(5)6)43(63)64-34(35(46)55)33(42(62)47-25(7)36(56)49-29)53-41(61)32(21-54)52-38(58)28(15-11-12-16-44)48-39(59)30(18-23(3)4)50-37(57)27(45)20-26-13-9-8-10-14-26/h8-10,13-14,22-25,27-34,54H,11-12,15-21,44-45H2,1-7H3,(H2,46,55)(H,47,62)(H,48,59)(H,49,56)(H,50,57)(H,51,60)(H,52,58)(H,53,61)/t25-,27-,28+,29-,30+,31-,32-,33?,34+/m0/s1
SMILES Code
O=C([C@H](OC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](C)N1)=O)=O)=O)C(NC([C@@H](NC([C@H](NC([C@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CC(C)C)=O)CCCCN)=O)CO)=O)C1=O)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. An antibiotic from an uncultured bacterium binds to an immutable target. Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22. PMID: 37611581. 2: Li X, Wu M, Shuai J. Clovibactin: A revolutionary antibiotic unleashing lethal efficacy against pathogens with little drug resistance. Sci Bull (Beijing). 2023 Dec 26:S2095-9273(23)00933-7. doi: 10.1016/j.scib.2023.12.047. Epub ahead of print. PMID: 38171960. 3: Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. A new antibiotic from an uncultured bacterium binds to an immutable target. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. doi: 10.1101/2023.05.15.540765. Update in: Cell. 2023 Aug 16;: PMID: 37292624; PMCID: PMC10245560. 4: Krumberger M, Li X, Kreutzer AG, Peoples AJ, Nitti AG, Cunningham AM, Jones CR, Achorn C, Ling LL, Hughes DE, Nowick JS. Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29. J Org Chem. 2023 Feb 17;88(4):2214-2220. doi: 10.1021/acs.joc.2c02648. Epub 2023 Jan 19. PMID: 36655882; PMCID: PMC9942206.