Synonym
BD 750; BD750; BD-750
IUPAC/Chemical Name
2-(benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol
InChi Key
QCIFTVIFOWJGTB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4,7-8,18H,1-2,5-6H2
SMILES Code
OC1=C2C(CCCC2)=NN1C3=NC4=C(S3)C=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
271.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu Y, Yang T, Li H, Li MH, Liu J, Wang YT, Yang SX, Zheng J, Luo XY, Lai Y,
Yang P, Li LM, Zou Q. BD750, a benzothiazole derivative, inhibits T cell
proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol.
2013 Feb;168(3):632-43. doi: 10.1111/j.1476-5381.2012.02172.x. PMID: 22906008;
PMCID: PMC3579284.
2: Zhou Y, Leng X, Li H, Yang S, Yang T, Li L, Xiong Y, Zou Q, Liu Y, Wang Y.
Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell
responses and experimental autoimmune encephalitis in mice. Mol Med. 2017
Oct;23:204-214. doi: 10.2119/molmed.2016.00110. Epub 2017 Sep 27. PMID:
28960227; PMCID: PMC5630474.
3: Yu Y, Bian Y, Shi JX, Gu Y, Yuan DP, Yu B, Shi L, Dou DH. Geniposide promotes
splenic Treg differentiation to alleviate colonic inflammation and intestinal
barrier injury in ulcerative colitis mice. Bioengineered. 2022
Jun;13(6):14616-14631. doi: 10.1080/21655979.2022.2092678. PMID: 36694912;
PMCID: PMC9995132.
