MedKoo Cat#: 125979 | Name: PD-1/PD-L1 Inhibitor N11
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD-1/PD-L1 inhibitor N11 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1; IC50 = 6.3 nM).

Chemical Structure

PD-1/PD-L1 Inhibitor N11
PD-1/PD-L1 Inhibitor N11
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125979

Name: PD-1/PD-L1 Inhibitor N11

CAS#: N/A

Chemical Formula: C26H27N5O

Exact Mass: 425.2216

Molecular Weight: 425.54

Elemental Analysis: C, 73.39; H, 6.40; N, 16.46; O, 3.76

Price and Availability

Size Price Availability Quantity
1mg USD 550.00 2 Weeks
5mg USD 1,050.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
PD-1/PD-L1 Inhibitor N11; PD-1/PD-L1 Interaction Inhibitor; Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor N11; PD-1/PD-L1
IUPAC/Chemical Name
2-methyl-2-(((4-(4-phenylindolin-1-yl)pyrido[3,2-d]pyrimidin-7-yl)methyl)amino)propan-1-ol
InChi Key
CZQOYRCWBPWJJP-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H27N5O/c1-26(2,16-32)30-15-18-13-22-24(27-14-18)25(29-17-28-22)31-12-11-21-20(9-6-10-23(21)31)19-7-4-3-5-8-19/h3-10,13-14,17,30,32H,11-12,15-16H2,1-2H3
SMILES Code
OCC(C)(C)NCC(C=N1)=CC2=C1C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=NC=N2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 425.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Meng Y, Wang Y, Zhang S, Yang Y, Wu D, Cui W, Niu X, Chu C, Wang L, Qin M. Novel 4-Arylindolines Containing a Pyrido[3,2-d]pyrimidine Moiety as the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Inhibitors for Tumor Immunotherapy. J Med Chem. 2023 Sep 14;66(17):11815-11830. doi: 10.1021/acs.jmedchem.3c00264. Epub 2023 Aug 19. PMID: 37596975.