NP3-562 is a Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitor (IC50 = 214 nM). NP3−562 demonstrates excellent potency in human whole blood and full inhibition of IL-1β release in a mouse acute peritonitis model at 30 mg/kg po dose. An X-ray structure of NP3−562 bound to the NLRP3 NACHT domain revealed a unique binding mode as compared to the known sulfonylurea-based inhibitors. In addition, NP3−562 shows also a good overall development profile.
MedKoo Cat#: 125972
Name: NP3-562
CAS#: N/A
Chemical Formula: C19H24ClN5O3S
Exact Mass: 437.1288
Molecular Weight: 437.94
Elemental Analysis: C, 52.11; H, 5.52; Cl, 8.09; N, 15.99; O, 10.96; S, 7.32
The following data is based on the product molecular weight 437.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
