MedKoo Cat#: 207203 | Name: STC-15
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

STC-15 is a potent METTL3 inhibitor. STC-15 inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. STC-15 has also been shown to inhibit tumor growth through mechanisms involving anti-cancer immune responses such as changes in interferon signaling and synergy with T cell checkpoint blockade. In addition, STC-15 has demonstrated efficacy in leukemia models via mechanisms such as inhibition of leukemia stem cell function.

Chemical Structure

STC-15
STC-15
CAS#2648257-56-9

Theoretical Analysis

MedKoo Cat#: 207203

Name: STC-15

CAS#: 2648257-56-9

Chemical Formula: C24H25N5O2

Exact Mass: 415.2008

Molecular Weight: 415.50

Elemental Analysis: C, 69.38; H, 6.07; N, 16.86; O, 7.70

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
50mg USD 1,650.00 2 Weeks
100mg USD 2,950.00 2 Weeks
1g USD 6,950.00 2 Weeks
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Related CAS #
No Data
Synonym
STC-15; STC 15; STC15;
IUPAC/Chemical Name
N-((2-(((cyclobutylmethyl)amino)methyl)-1H-indol-6-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide
InChi Key
MFQFZLWCFZZHAI-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H25N5O2/c30-23-12-21(28-22-6-1-2-9-29(22)23)24(31)26-14-17-7-8-18-11-19(27-20(18)10-17)15-25-13-16-4-3-5-16/h1-2,6-12,16,25,27H,3-5,13-15H2,(H,26,31)
SMILES Code
O=C1C=C(C(NCC2=CC3=C(C=C(CNCC4CCC4)N3)C=C2)=O)N=C5C=CC=CN15
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 415.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Wesley Peter Blackaby, et al. Polyheterocyclic compounds as mettl3 inhibitors. Patent WO2021111124A1.