MedKoo Cat#: 125894 | Name: LY-237

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-237 is a GPR84 agonist (cAMP EC50 = 0.352 nM).

Chemical Structure

LY-237
LY-237
CAS#1892576-07-6

Theoretical Analysis

MedKoo Cat#: 125894

Name: LY-237

CAS#: 1892576-07-6

Chemical Formula: C14H23NO2

Exact Mass: 237.1729

Molecular Weight: 237.34

Elemental Analysis: C, 70.85; H, 9.77; N, 5.90; O, 13.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY-237; LY237; LY 237
IUPAC/Chemical Name
6-nonylpyridine-2,4-diol
InChi Key
JCINCSYDDSRQQC-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H23NO2/c1-2-3-4-5-6-7-8-9-12-10-13(16)11-14(17)15-12/h10-11H,2-9H2,1H3,(H2,15,16,17)
SMILES Code
OC1=CC(O)=CC(CCCCCCCCC)=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists Amit Mahindra, Laura Jenkins, Sara Marsango, Mark Huggett, Margaret Huggett, Lindsay Robinson, Jonathan Gillespie, Muralikrishnan Rajamanickam, Angus Morrison, Stuart McElroy, Irina G. Tikhonova, Graeme Milligan, and Andrew G. Jamieson Journal of Medicinal Chemistry 2022 65 (16), 11270-11290 DOI: 10.1021/acs.jmedchem.2c00804