CD649.2 is a Cu(II)-responsive, activity-based sensing fluorescent probe with metal and oxidation state selectivity and is capable of detecting changes in labile intracellular Cu(II) pools by live-cell confocal microscopy. CD649.2 provides foundational information on the existence and regulation of labile Cu(II) pools, including identifying divalent metal transporter 1 (DMT1) as a Cu(II) importer, labile Cu(II) increases in response to oxidative stress induced by depleting total glutathione levels, and reciprocal increases in labile Cu(II) accompanied by decreases in labile Cu(I) induced by oncogenic mutations that promote oxidative stress.
MedKoo Cat#: 556359
Name: CD649.2
CAS#: N/A
Chemical Formula: C42H52N6O8SSi
Exact Mass: 828.3337
Molecular Weight: 829.06
Elemental Analysis: C, 60.85; H, 6.32; N, 10.14; O, 15.44; S, 3.87; Si, 3.39
The following data is based on the product molecular weight 829.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
