MedKoo Cat#: 125771 | Name: EM12-SO2F
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM).

Chemical Structure

EM12-SO2F
EM12-SO2F
CAS#2803819-61-4

Theoretical Analysis

MedKoo Cat#: 125771

Name: EM12-SO2F

CAS#: 2803819-61-4

Chemical Formula: C13H11FN2O5S

Exact Mass: 326.0400

Molecular Weight: 326.30

Elemental Analysis: C, 47.85; H, 3.40; F, 5.82; N, 8.59; O, 24.52; S, 9.83

Price and Availability

Size Price Availability Quantity
10mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
EM12-SO2F; EM12SO2F; EM12 SO2F
IUPAC/Chemical Name
2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindoline-5-sulfonyl fluoride
InChi Key
IAJNULNMWPZFDR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11FN2O5S/c14-22(20,21)8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
SMILES Code
O=C1NC(C(CC1)N2C(C3=CC(S(=O)(F)=O)=CC=C3C2)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 326.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Dann GP, Liu H, Nowak RP, Jones LH. Cereblon target validation using a covalent inhibitor of neosubstrate recruitment. Methods Enzymol. 2023;681:155-167. doi: 10.1016/bs.mie.2022.08.056. Epub 2022 Dec 30. PMID: 36764755.