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MedKoo Cat#: 125653 | Name: VCP-171

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VCP-171 is an A1AR PAM

Chemical Structure

VCP-171
VCP-171
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125653

Name: VCP-171

CAS#: N/A

Chemical Formula: C18H12F3NOS

Exact Mass: 347.0600

Molecular Weight: 347.36

Elemental Analysis: C, 62.24; H, 3.48; F, 16.41; N, 4.03; O, 4.61; S, 9.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VCP-171; VCP 171; VCP171
IUPAC/Chemical Name
(2-amino-4-(3-(trifluoromethyl)phenyl)thiophen-3-yl)(phenyl)methanone
InChi Key
HNHLVOBHWXLIGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2
SMILES Code
[H]C1=CC(C(F)(F)F)=CC(C2=CSC(N)=C2C(C3=CC=C([H])C=C3)=O)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miao Y, Bhattarai A, Nguyen ATN, Christopoulos A, May LT. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor. Sci Rep. 2018 Nov 15;8(1):16836. doi: 10.1038/s41598-018-35266-x. PMID: 30442899; PMCID: PMC6237911. 2: Deganutti G, Barkan K, Ladds G, Reynolds CA. Multisite Model of Allosterism for the Adenosine A1 Receptor. J Chem Inf Model. 2021 Apr 26;61(4):2001-2015. doi: 10.1021/acs.jcim.0c01331. Epub 2021 Mar 29. PMID: 33779168. 3: Cooper SL, Soave M, Jörg M, Scammells PJ, Woolard J, Hill SJ. Probe dependence of allosteric enhancers on the binding affinity of adenosine A1 -receptor agonists at rat and human A1 -receptors measured using NanoBRET. Br J Pharmacol. 2019 Apr;176(7):864-878. doi: 10.1111/bph.14575. Epub 2019 Mar 6. PMID: 30644086; PMCID: PMC6433648. 4: Nguyen AT, Vecchio EA, Thomas T, Nguyen TD, Aurelio L, Scammells PJ, White PJ, Sexton PM, Gregory KJ, May LT, Christopoulos A. Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity. Mol Pharmacol. 2016 Dec;90(6):715-725. doi: 10.1124/mol.116.105015. Epub 2016 Sep 28. PMID: 27683013. 5: Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ. A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol Pharmacol. 2015 Sep;88(3):460-8. doi: 10.1124/mol.115.099499. Epub 2015 Jun 23. PMID: 26104547.