VCP-171 | A1AR PAM

MedKoo Cat#: 125653 | Name: VCP-171

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VCP-171 is an A1AR PAM

Chemical Structure

VCP-171

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125653

Name: VCP-171

CAS#: N/A

Chemical Formula: C18H12F3NOS

Exact Mass: 347.0600

Molecular Weight: 347.36

Elemental Analysis: C, 62.24; H, 3.48; F, 16.41; N, 4.03; O, 4.61; S, 9.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VCP-171; VCP 171; VCP171

IUPAC/Chemical Name

(2-amino-4-(3-(trifluoromethyl)phenyl)thiophen-3-yl)(phenyl)methanone

InChi Key

HNHLVOBHWXLIGP-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2

SMILES Code

[H]C1=CC(C(F)(F)F)=CC(C2=CSC(N)=C2C(C3=CC=C([H])C=C3)=O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 347.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miao Y, Bhattarai A, Nguyen ATN, Christopoulos A, May LT. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor. Sci Rep. 2018 Nov 15;8(1):16836. doi: 10.1038/s41598-018-35266-x. PMID: 30442899; PMCID: PMC6237911. 2: Deganutti G, Barkan K, Ladds G, Reynolds CA. Multisite Model of Allosterism for the Adenosine A1 Receptor. J Chem Inf Model. 2021 Apr 26;61(4):2001-2015. doi: 10.1021/acs.jcim.0c01331. Epub 2021 Mar 29. PMID: 33779168. 3: Cooper SL, Soave M, Jörg M, Scammells PJ, Woolard J, Hill SJ. Probe dependence of allosteric enhancers on the binding affinity of adenosine A₁ -receptor agonists at rat and human A₁ -receptors measured using NanoBRET. Br J Pharmacol. 2019 Apr;176(7):864-878. doi: 10.1111/bph.14575. Epub 2019 Mar 6. PMID: 30644086; PMCID: PMC6433648. 4: Nguyen AT, Vecchio EA, Thomas T, Nguyen TD, Aurelio L, Scammells PJ, White PJ, Sexton PM, Gregory KJ, May LT, Christopoulos A. Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity. Mol Pharmacol. 2016 Dec;90(6):715-725. doi: 10.1124/mol.116.105015. Epub 2016 Sep 28. PMID: 27683013. 5: Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ. A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol Pharmacol. 2015 Sep;88(3):460-8. doi: 10.1124/mol.115.099499. Epub 2015 Jun 23. PMID: 26104547.