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MedKoo Cat#: 125645 | Name: DW34

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DW34 is a BETBD1 bromodomain inhibitor.

Chemical Structure

DW34
DW34
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125645

Name: DW34

CAS#: N/A

Chemical Formula: C25H34N6O

Exact Mass: 434.2800

Molecular Weight: 434.59

Elemental Analysis: C, 69.09; H, 7.89; N, 19.34; O, 3.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
DW34; DW-34; DW 34
IUPAC/Chemical Name
2-(4-(5-(6-(3,5-dimethylphenoxy)pyridin-2-yl)-4-methyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-N,N-dimethylethan-1-amine
InChi Key
PIKWYDHWUKSWAQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H34N6O/c1-18-15-19(2)17-22(16-18)32-24-8-6-7-23(26-24)25-20(3)27-28-31(25)21-9-11-30(12-10-21)14-13-29(4)5/h6-8,15-17,21H,9-14H2,1-5H3
SMILES Code
CC1=C(C2=CC=CC(OC3=CC(C)=CC(C)=C3)=N2)N(C4CCN(CCN(C)C)CC4)N=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK. 4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. J Med Chem. 2021 Jul 22;64(14):10497-10511. doi: 10.1021/acs.jmedchem.1c00933. Epub 2021 Jul 8. PMID: 34236185; PMCID: PMC8491147. 2: Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, Ikuta K. Lymphocyte- stromal cell interaction induces IL-7 expression by interferon regulatory factors. Mol Immunol. 2013 Jul;54(3-4):378-85. doi: 10.1016/j.molimm.2013.01.002. Epub 2013 Jan 30. PMID: 23376291. 3: Nagasawa T, Kikutani H, Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2305-9. doi: 10.1073/pnas.91.6.2305. PMID: 8134392; PMCID: PMC43359. 4: Nakayama T, Mutsuga N, Tosato G. Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and hematopoiesis. J Natl Cancer Inst. 2007 Feb 7;99(3):223-35. doi: 10.1093/jnci/djk031. PMID: 17284717. 5: Kaisho T, Oritani K, Ishikawa J, Tanabe M, Muraoka O, Ochi T, Hirano T. Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth. J Immunol. 1992 Dec 15;149(12):4088-95. PMID: 1281201.