PF-07265028 is a HPK1inhibitor with IC50 = 17 nM. PF-07265028 was advanced toin vivo pharmacokinetic studies and showed moderateclearance, terminal half-life, volume of distribution and oralbioavailability in mice and monkeys. PF-07265028 targets, binds to and inhibits the activity of Hpk1. This inhibits Hpk1-mediated signaling pathways and prevents Hpk1-mediated immunosuppression by preventing the inhibition of T-cell receptors (TCR) signaling and effector T cells, disrupting abnormal cytokine expression, and abrogating the immunosuppressive tumor microenvironment (TME). This may activate a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Hpk1, expressed in hematopoietic cells, is a negative regulator of TCR signaling and T- and B-cell activation.
MedKoo Cat#: 125629
Name: PF-07265028
CAS#: 2736458-30-1
Chemical Formula: C25H31N9O
Exact Mass: 473.2700
Molecular Weight: 473.59
Elemental Analysis: C, 63.40; H, 6.60; N, 26.62; O, 3.38
The following data is based on the product molecular weight 473.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
