ART838 is a 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology. ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. ART-838 was 88-fold more potent that artesunate in vitro, inhibiting all leukemia cell lines at submicromolar concentrations. Both ART-838 and artesunate cooperated with several established antileukemic drugs and newer kinase inhibitors to inhibit leukemia cell growth. ART-838 had a longer plasma half-life than artesunate in immunodeficient NOD-SCID-IL2Rgnull (NSG) mice, remaining at effective antileukemic concentrations for >8h. Intermittent cycles of ART-838 inhibited growth of acute leukemia xenografts and primagrafts in NSG mice, at higher potency than artesunate .
MedKoo Cat#: 556356
Name: ART838
CAS#: 676620-45-4
Chemical Formula: C46H63O12P
Exact Mass: 838.4057
Molecular Weight: 838.97
Elemental Analysis: C, 65.86; H, 7.57; O, 22.88; P, 3.69
The following data is based on the product molecular weight 838.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
