ART631 | CAS#1426680-31-0

MedKoo Cat#: 556355 | Name: ART631

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ART631 is a 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology.

Chemical Structure

ART631

CAS#1426680-31-0

Theoretical Analysis

MedKoo Cat#: 556355

Name: ART631

CAS#: 1426680-31-0

Chemical Formula: C35H53NO9

Exact Mass: 631.3720

Molecular Weight: 631.81

Elemental Analysis: C, 66.54; H, 8.46; N, 2.22; O, 22.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ART631; ART-631; ART 631;

IUPAC/Chemical Name

(Z)-2-((3R,6R,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)-1-((3R,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)ethan-1-one O-allyl oxime

InChi Key

WGDOECSYODBCCA-VYSFZWTDSA-N

InChi Code

InChI=1S/C35H53NO9/c1-8-17-37-36-27(29-22(5)26-12-10-20(3)24-14-16-33(7)41-31(39-29)35(24,26)45-43-33)18-28-21(4)25-11-9-19(2)23-13-15-32(6)40-30(38-28)34(23,25)44-42-32/h8,19-26,28-31H,1,9-18H2,2-7H3/b36-27-/t19-,20-,21-,22-,23?,24?,25?,26?,28-,29+,30-,31-,32-,33-,34-,35-/m1/s1

SMILES Code

C[C@@H]1CCC2[C@]34C1CC[C@@](C)(OO4)O[C@H]3O[C@H](C/C([C@H]5O[C@@H]6O[C@](C)(OO7)CCC8[C@@]67C([C@H]5C)CC[C@H]8C)=N/OCC=C)[C@@H]2C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 631.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Kagan AB, Moses BS, Lapidus R, Mott BT, Rai G, Anders NM, Hoag SW, Rudek MA, Civin CI. ART714 is a best-in-class antileukemic 2-carbon-linked dimeric artemisinin derivative. Cancer Chemother Pharmacol. 2023 Jul;92(1):39-50. doi: 10.1007/s00280-023-04539-2. Epub 2023 May 30. PMID: 37249624. 2. Kagan AB, Moses BS, Mott BT, Rai G, Anders NM, Rudek MA, Civin CI. A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology. Front Oncol. 2022 Jan 11;11:790037. doi: 10.3389/fonc.2021.790037. PMID: 35127495; PMCID: PMC8811960.