TU-100 | gastrointestinal dysmotility | CAS#1310907-71-1

MedKoo Cat#: 125482 | Name: TU-100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TU-100 is traditionally used in the treatment of chronic gastrointestinal disorders, and often prescribed to relieve abdominal pain, abdominal distention, Crohn’s disease, irritable bowel syndrome, adhesive ileus, and paralytic ileus. TU-100 improves gastrointestinal dysmotility and reduces serum CRP levels in patients with grade B liver damage after hepatectomy.

Chemical Structure

TU-100

CAS#1310907-71-1

Theoretical Analysis

MedKoo Cat#: 125482

Name: TU-100

CAS#: 1310907-71-1

Chemical Formula: C20H13NO3

Exact Mass: 315.0900

Molecular Weight: 315.33

Elemental Analysis: C, 76.18; H, 4.16; N, 4.44; O, 15.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TU-100; TU100; TU 100; Daikenchuto

IUPAC/Chemical Name

14-methyl-5H-5,12-epiminobenzo[4,5]cyclohepta[1,2-b]naphthalene-6,11,13(12H)-trione

InChi Key

KAYRGFYBCCETPE-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H13NO3/c1-21-16-10-6-2-3-7-11(10)20(24)17(21)15-14(16)18(22)12-8-4-5-9-13(12)19(15)23/h2-9,16-17H,1H3

SMILES Code

CN1C2C3=C(C1C4=C(C=CC=C4)C2=O)C(=O)C5=C(C=CC=C5)C3=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 315.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yamada S, Morine Y, Imura S, Ikemoto T, Saito Y, Shimizu M, Tsuneyama K, Nishiyama M, Ishizawa S, Shimada M. Effect of daikenchuto (TU-100) on carcinogenesis in non-alcoholic steatohepatitis. J Med Invest. 2023;70(1.2):66-73. doi: 10.2152/jmi.70.66. PMID: 37164745. 2: Takasu C, Miyazaki K, Yoshikawa K, Nishi M, Tokunaga T, Kashihara H, Yoshimoto T, Ogawa H, Morine Y, Shimada M. Effect of TU-100 on Peyer's patches in a bacterial translocation rat model. Ann Gastroenterol Surg. 2021 Apr 5;5(5):683-691. doi: 10.1002/ags3.12460. PMID: 34585053; PMCID: PMC8452476. 3: Chen S, Morine Y, Saito YU, Yamada S, Teraoku H, Ikemoto T, Shimada M. TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-B/STAT3 Axis. Anticancer Res. 2023 May;43(5):1985-1992. doi: 10.21873/anticanres.16359. PMID: 37097685. 4: Takasu C, Yismaw WG, Kurita N, Yoshikawa K, Kashihara H, Kono T, Shimada M. TU-100 exerts a protective effect against bacterial translocation by maintaining the tight junction. Surg Today. 2017 Oct;47(10):1287-1294. doi: 10.1007/s00595-017-1518-6. Epub 2017 Apr 18. PMID: 28421347. 5: Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe- independent effects involving Akt and NF-κB suppression. PLoS One. 2014 May 23;9(5):e97456. doi: 10.1371/journal.pone.0097456. PMID: 24857966; PMCID: PMC4032249. 6: Wada Y, Tokuda K, Morine Y, Okikawa S, Yamashita S, Ikemoto T, Imura S, Saito Y, Yamada S, Shimada M. The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment. Oncotarget. 2020 Dec 8;11(49):4593-4604. doi: 10.18632/oncotarget.27835. PMID: 33346211; PMCID: PMC7733620. 7: Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC^min/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 Jan;31(1):90-99. doi: 10.1002/ptr.5735. Epub 2016 Oct 12. PMID: 27730672; PMCID: PMC5590753. 8: Hasebe T, Ueno N, Musch MW, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Kono T, Inaba Y, Fujiya M, Kohgo Y, Chang EB. Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K. Pharmacol Res Perspect. 2016 Feb 10;4(1):e00215. doi: 10.1002/prp2.215. PMID: 26977303; PMCID: PMC4777267. 9: Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, Noguchi M, Watanabe T. Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model. J Gastroenterol. 2011 Oct;46(10):1187-96. doi: 10.1007/s00535-011-0438-2. Epub 2011 Aug 2. PMID: 21808981. 10: Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB. Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect. 2017 Oct;5(5):e00361. doi: 10.1002/prp2.361. PMID: 28971602; PMCID: PMC5625165.