STX-721 is a Exon 20 Mutant EGFR Inhibitor. STX-721 demonstrated strong EGFR exon 20 mutant potency and selectivity in isogenic Ba/F3 models and human cancer cell lines, as well as signaling and biochemical assays. STX-721 demonstrated strong in vivo anti-tumor activity across a variety of EGFR and HER2 exon 20 mutant cell line-derived xenograft (“CDX”) and patient-derived xenograft (“PDX”) models. STX-721 also demonstrated a clear exon 20 genotype-selective in vivo efficacy window in isogenic cancer CDX models.
MedKoo Cat#: 125437
Name: STX-721
CAS#: N/A
Chemical Formula: C32H35ClN6O3
Exact Mass: 586.2500
Molecular Weight: 587.12
Elemental Analysis: C, 65.46; H, 6.01; Cl, 6.04; N, 14.31; O, 8.17
The following data is based on the product molecular weight 587.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
