Z11 is a selective and potent macrocyclic CDK9 inhibitor (IC50 = 3.20 nM) for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. Z11 showes good kinase selectivity,significantly inhibits cell proliferation and colony formation and induces apoptosis in Osimertinib-resistant H1975 cells. Furthermore, Z11 demonstrates a significant suppression of tumor growth in six patient-derived organoids, including three organoids resistant to Osimertinib. Overall, Z11 served as a promising macrocycle-based CDK9 inhibitor for treating Osimertinib-resistant NSCLC.
MedKoo Cat#: 125434
Name: Z11
CAS#: N/A
Chemical Formula: C29H33F2N5O4
Exact Mass: 553.2500
Molecular Weight: 553.61
Elemental Analysis: C, 62.92; H, 6.01; F, 6.86; N, 12.65; O, 11.56
The following data is based on the product molecular weight 553.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
