MZ325 is a potent and selective inhibitor of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6). MZ325 showed IC50 (HDAC6) = 43 nM, and IC50 (Sirt2) = 320 nM. Inhibition of both targets was further confirmed by X-ray crystal structures of Sirt2 and HDAC6 in complex with building blocks of MZ325. In ovarian cancer cells, MZ325 evoked enhanced effects on cell viability compared to single or combination treatment with the unconjugated Sirt2 and HDAC6 inhibitors.
MedKoo Cat#: 125426
Name: MZ325
CAS#: N/A
Chemical Formula: C38H45N9O5S2
Exact Mass: 771.3000
Molecular Weight: 771.96
Elemental Analysis: C, 59.12; H, 5.88; N, 16.33; O, 10.36; S, 8.31
The following data is based on the product molecular weight 771.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
