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MedKoo Cat#: 125410 | Name: Norketamine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norketamine is one of the major metabolites of Ketamine, which is routinely used as an anesthetic.

Chemical Structure

Norketamine HCl
Norketamine HCl
CAS#79499-59-5

Theoretical Analysis

MedKoo Cat#: 125410

Name: Norketamine HCl

CAS#: 79499-59-5

Chemical Formula: C12H15Cl2NO

Exact Mass: 259.0500

Molecular Weight: 260.16

Elemental Analysis: C, 55.40; H, 5.81; Cl, 27.25; N, 5.38; O, 6.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Norketamine hydrochloride; 79499-59-5; Cyclohexanone, 2-amino-2-(2-chlorophenyl)-, hydrochloride; (+/-)-Norketamine hydrochloride; QA4F2IDL56
IUPAC/Chemical Name
2-amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
InChi Key
CLPOJGPBUGCUKT-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H14ClNO.ClH/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15;/h1-2,5-6H,3-4,7-8,14H2;1H
SMILES Code
Cl.NC1(CCCCC1=O)C2=C(Cl)C=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kamp J, Jonkman K, van Velzen M, Aarts L, Niesters M, Dahan A, Olofsen E. Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis. Br J Anaesth. 2020 Nov;125(5):750-761. doi: 10.1016/j.bja.2020.06.067. Epub 2020 Aug 21. PMID: 32838982. 2: Hernando MV, Moore JC, Howie RA, Castledine RA, Bourne SL, Jenkins GN, Licence P, Poliakoff M, George MW. High Yielding Continuous-Flow Synthesis of Norketamine. Org Process Res Dev. 2022 Apr 15;26(4):1145-1151. doi: 10.1021/acs.oprd.1c00407. Epub 2022 Mar 26. PMID: 35573033; PMCID: PMC9098192. 3: Pérez-Pereira A, Ribeiro C, Teles F, Gonçalves R, M F Gonçalves V, Pereira JA, Carrola JS, Pires C, Tiritan ME. Ketamine and Norketamine: Enantioresolution and Enantioselective Aquatic Ecotoxicity Studies. Environ Toxicol Chem. 2022 Mar;41(3):569-579. doi: 10.1002/etc.4955. Epub 2021 Mar 10. PMID: 33289946. 4: Göktaş EF, Arıöz F. A review of chromatographic methods for ketamine and its metabolites norketamine and dehydronorketamine. Biomed Chromatogr. 2018 Jan;32(1). doi: 10.1002/bmc.4014. Epub 2017 Jul 11. PMID: 28555942.