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MedKoo Cat#: 125330 | Name: Cholylsarcosine sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cholylsarcosine is a synthetic deconjugation-resistant and nonsecretory conjugated bile acid analog for the treatment of fat malabsorption caused by severe bile acid malabsorption.

Chemical Structure

Cholylsarcosine sodium
Cholylsarcosine sodium
CAS#165048-60-2

Theoretical Analysis

MedKoo Cat#: 125330

Name: Cholylsarcosine sodium

CAS#: 165048-60-2

Chemical Formula: C27H44NNaO6

Exact Mass: 501.3100

Molecular Weight: 501.64

Elemental Analysis: C, 64.65; H, 8.84; N, 2.79; Na, 4.58; O, 19.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cholylsarcosine sodium; Sodium N-methylglycocholate; Sodium N-methylglycylcholate; UNII-0026F8BCCU; 0026F8BCCU
IUPAC/Chemical Name
sodium N-methyl-N-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycinate
InChi Key
VHVDQXUBFQWQAU-QPHXFTIQSA-M
InChi Code
InChI=1S/C27H45NO6.Na/c1-15(5-8-23(32)28(4)14-24(33)34)18-6-7-19-25-20(13-22(31)27(18,19)3)26(2)10-9-17(29)11-16(26)12-21(25)30;/h15-22,25,29-31H,5-14H2,1-4H3,(H,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,25+,26+,27-;/m1./s1
SMILES Code
[Na+].[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)[C@H](C)CCC(=O)N(C)CC([O-])=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 501.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Longmire-Cook SJ, Lillienau J, Kim YS, Schteingart CD, Danzinger RG, Esch O, Hofmann AF. Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection. Dig Dis Sci. 1992 Aug;37(8):1217-27. doi: 10.1007/BF01296563. PMID: 1379904. 2: Chen X, Chen F, Liu S, Glaeser H, Dawson PA, Hofmann AF, Kim RB, Shneider BL, Pang KS. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Mol Pharmacol. 2006 Jun;69(6):1913-23. doi: 10.1124/mol.105.020792. Epub 2006 Feb 15. PMID: 16481392. 3: Parmentier J, Becker MM, Heintz U, Fricker G. Stability of liposomes containing bio-enhancers and tetraether lipids in simulated gastro-intestinal fluids. Int J Pharm. 2011 Feb 28;405(1-2):210-7. doi: 10.1016/j.ijpharm.2010.12.005. Epub 2010 Dec 9. PMID: 21145956.