T-2513 | selective topoisomerase I inhibitor | CAS#288247-87-0

MedKoo Cat#: 125311 | Name: T-2513

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-2513 is a selective topoisomerase I inhibitor.

Chemical Structure

T-2513

CAS#288247-87-0

Theoretical Analysis

MedKoo Cat#: 125311

Name: T-2513

CAS#: 288247-87-0

Chemical Formula: C25H27N3O5

Exact Mass: 449.2000

Molecular Weight: 449.51

Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

T-2513; 288247-87-0; 20Y8Q506KT; T 2513; UNII-20Y8Q506KT; T2513

IUPAC/Chemical Name

(S)-9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

InChi Key

XZLHHOGJQUVONU-VWLOTQADSA-N

InChi Code

InChI=1S/C25H27N3O5/c1-3-15-16-10-14(32-9-5-8-26)6-7-20(16)27-22-17(15)12-28-21(22)11-19-18(23(28)29)13-33-24(30)25(19,31)4-2/h6-7,10-11,31H,3-5,8-9,12-13,26H2,1-2H3/t25-/m0/s1

SMILES Code

CCC1=C2CN3C(=CC4=C(COC(=O)[C@]4(O)CC)C3=O)C2=NC5=CC=C(OCCCN)C=C15

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 449.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harada M, Imai J, Okuno S, Suzuki T. Macrophage-mediated activation of camptothecin analogue T-2513-carboxymethyl dextran conjugate (T-0128): possible cellular mechanism for antitumor activity. J Control Release. 2000 Dec 3;69(3):389-97. doi: 10.1016/s0168-3659(00)00320-5. PMID: 11102679. 2: Fujita F, Koike M, Fujita M, Sakamoto Y, Okuno S, Kawaguchi T, Yano S, Yano T, Kiuchi S, Fujiwara T, Kudoh S, Kakushima M. MEN4901/T-0128, a new camptothecin derivative-carboxymethyldextran conjugate, has potent antitumor activities in a panel of human tumor xenografts in nude mice. Clin Cancer Res. 2005 Feb 15;11(4):1650-7. doi: 10.1158/1078-0432.CCR-04-1756. PMID: 15746070. 3: Ma H, Li X, Yang Z, Okuno S, Kawaguchi T, Yagi S, Bouvet M, Hoffman RM. High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate. J Surg Res. 2011 Dec;171(2):684-90. doi: 10.1016/j.jss.2010.05.066. Epub 2010 Jun 25. PMID: 20851421; PMCID: PMC3008337. 4: Harada M, Sakakibara H, Yano T, Suzuki T, Okuno S. Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate. J Control Release. 2000 Dec 3;69(3):399-412. doi: 10.1016/s0168-3659(00)00321-7. PMID: 11102680.