Synonym
4-Hydroxy-3-methoxymethamphetamine; 117652-28-5; RBY3J6H4JW; 4,3-Hmm; 2-Methoxy-4-(2-(methylamino)propyl)phenol
IUPAC/Chemical Name
2-methoxy-4-(2-(methylamino)propyl)phenol
InChi Key
UVDWYWYWOMOEFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17NO2/c1-8(12-2)6-9-4-5-10(13)11(7-9)14-3/h4-5,7-8,12-13H,6H2,1-3H3
SMILES Code
CNC(C)CC1=CC=C(O)C(OC)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
195.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schwaninger AE, Meyer MR, Maurer HH. Investigation on the enantioselectivity
of the sulfation of the methylenedioxymethamphetamine metabolites
3,4-dihydroxymethamphetamine and 4-hydroxy-3-methoxymethamphetamine using the
substrate-depletion approach. Drug Metab Dispos. 2011 Nov;39(11):1998-2002. doi:
10.1124/dmd.111.041129. Epub 2011 Jul 27. PMID: 21795466.
2: Shima N, Katagi M, Kamata H, Zaitsu K, Kamata T, Nishikawa M, Miki A,
Tsuchihashi H, Sakuma T, Nemoto N. Urinary excretion of the main metabolites of
3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide
of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats. Xenobiotica.
2008 Mar;38(3):314-24. doi: 10.1080/00498250701802506. PMID: 18274959.
3: Mueller M, Peters FT, Ricaurte GA, Maurer HH. Validated liquid
chromatographic-electrospray ionization mass spectrometric assay for
simultaneous determination of 3,4-methylenedioxymethamphetamine and its
metabolites 3,4-methylenedioxyamphetamine, 3,4-dihydroxymethamphetamine, and
4-hydroxy-3-methoxymethamphetamine in squirrel monkey plasma. J Chromatogr B
Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):262-70. doi:
10.1016/j.jchromb.2007.06.034. Epub 2007 Jul 6. PMID: 17646137; PMCID:
PMC2682589.
4: Shima N, Kamata H, Katagi M, Tsuchihashi H, Sakuma T, Nemoto N. Direct
determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine,
the main metabolite of MDMA, in human urine. J Chromatogr B Analyt Technol
Biomed Life Sci. 2007 Sep 15;857(1):123-9. doi: 10.1016/j.jchromb.2007.07.003.
Epub 2007 Jul 10. PMID: 17643356.
5: Dunand M, Donzelli M, Rickli A, Hysek CM, Liechti ME, Grouzmann E. Analytical
interference of 4-hydroxy-3-methoxymethamphetamine with the measurement of
plasma free normetanephrine by ultra-high pressure liquid chromatography-tandem
mass spectrometry. Clin Biochem. 2014 Aug;47(12):1121-3. doi:
10.1016/j.clinbiochem.2014.04.003. Epub 2014 Apr 13. PMID: 24731790.
