Synonym
PK-10; PK10; PK 10
IUPAC/Chemical Name
(E)-3-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-1-(4-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)phenyl)prop-2-en-1-one
InChi Key
SINLLFFCVCSBBD-XNTDXEJSSA-N
InChi Code
InChI=1S/C35H36F3N5O/c1-40-16-20-43(21-17-40)34-29(24-28-4-2-3-5-32(28)39-34)10-15-33(44)27-8-13-31(14-9-27)42-22-18-41(19-23-42)25-26-6-11-30(12-7-26)35(36,37)38/h2-15,24H,16-23,25H2,1H3/b15-10+
SMILES Code
O=C(C1=CC=C(N2CCN(CC2)CC3=CC=C(C(F)(F)F)C=C3)C=C1)/C=C/C4=CC5=C(N=C4N6CCN(CC6)C)C=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
599.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Blahos J 2nd, Whalin ME, Krueger KE. Identification and purification of a
10-kilodalton protein associated with mitochondrial benzodiazepine receptors. J
Biol Chem. 1995 Sep 1;270(35):20285-91. doi: 10.1074/jbc.270.35.20285. PMID:
7657598.
2: Dickson LB, Campbell CL, Juneja P, Jiggins FM, Sylla M, Black WC 4th. Exon-
Enriched Libraries Reveal Large Genic Differences Between Aedes aegypti
from Senegal, West Africa, and Populations Outside Africa. G3 (Bethesda). 2017
Feb 9;7(2):571-582. doi: 10.1534/g3.116.036053. PMID: 28007834; PMCID:
PMC5295602.
3: Campbell CL, Dickson LB, Lozano-Fuentes S, Juneja P, Jiggins FM, Black WC
4th. Alternative patterns of sex chromosome differentiation in Aedes aegypti
(L). BMC Genomics. 2017 Dec 4;18(1):943. doi: 10.1186/s12864-017-4348-4. PMID:
29202694; PMCID: PMC5716240.
4: Olé Sangba ML, Sidick A, Govoetchan R, Dide-Agossou C, Ossè RA, Akogbeto M,
Ndiath MO. Evidence of multiple insecticide resistance mechanisms in Anopheles
gambiae populations in Bangui, Central African Republic. Parasit Vectors. 2017
Jan 13;10(1):23. doi: 10.1186/s13071-016-1965-8. PMID: 28086840; PMCID:
PMC5237250.
