ME -143 is a derivative of triphendiol and is a highly potent, pan acting ant-cancer. It is active against every melanoma cell line tested to date and is able to sensitize melanoma cell lines to the standard of care drug, dacarbazine, and members of the platinum drug scaffold. Proof of concept studies in animal models of melanoma have demonstrated that orally delivered ME-143 retards tumour proliferation. The ME-143 mechanism of action in melanoma has not been fully elucidated. ME-143 is non-clastogenic.
MedKoo Cat#: 205782
Name: ME-143
CAS#: 852536-39-1
Chemical Formula: C21H18O4
Exact Mass: 334.1205
Molecular Weight: 334.37
Elemental Analysis: C, 75.43; H, 5.43; O, 19.14
The following data is based on the product molecular weight 334.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
