Synonym
PF-07202954; PF 07202954; PF07202954
IUPAC/Chemical Name
2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-((3S,5S)-5-fluoropiperidin-3-yl)pyrimidine-5-carboxamide
InChi Key
CPBXJSPVZIPJMX-IRXDYDNUSA-N
InChi Code
InChI=1S/C22H23FN6O3/c1-2-31-19-4-3-5-26-22(19)32-18-6-14(8-24-13-18)20-27-9-15(10-28-20)21(30)29-17-7-16(23)11-25-12-17/h3-6,8-10,13,16-17,25H,2,7,11-12H2,1H3,(H,29,30)/t16-,17-/m0/s1
SMILES Code
CCOC1=CC=CN=C1OC2=CN=CC(C3=NC=C(C(N[C@@H]4CNC[C@@H](F)C4)=O)C=N3)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
438.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life
Kevin J. Filipski, David J. Edmonds, Michelle R. Garnsey, Daniel J. Smaltz, Karen Coffman, Kentaro Futatsugi, Jack Lee, Steven V. O’Neil, Ann Wright, Deane Nason, James R. Gosset, Christine C. Orozco, Dan Blackler, Guila Fakhoury, Jemy A. Gutierrez, Sylvie Perez, Trenton Ross, Ingrid Stock, Gregory Tesz, and Robert Dullea
ACS Medicinal Chemistry Letters 2023 14 (10), 1427-1433
DOI: 10.1021/acsmedchemlett.3c00330
