UNC9512 is a a 3BP1 Antagonist. UNC9512 binds the TTD with an IC50 value of 0.46 ± 0.21 μM. UNC9512 demonstrated submicromolar affinity by TR-FRET (0.46 ± 0.21 μM) and protein stabilization by DSF (+4.1 ± 0.3 °C), as well as similar Kd measurements in SPR (0.17 ± 0.02 μM) and ITC (0.41 ± 0.17 μM) assays with ∼4-fold and ∼2-fold improvements over UNC8531, respectively.
MedKoo Cat#: 125199
Name: UNC9512
CAS#: N/A
Chemical Formula: C31H34N6O3
Exact Mass: 538.2700
Molecular Weight: 538.65
Elemental Analysis: C, 69.12; H, 6.36; N, 15.60; O, 8.91
The following data is based on the product molecular weight 538.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
