Synonym
DJ4; D-J4; D J4; EX-A7863; EXA7863; EX A7863; NSC781419; NSC781773; NSC-781419
IUPAC/Chemical Name
(2E,5Z)-5-((3a,7a-dihydro-1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-(phenethylimino)thiazolidin-4-one
InChi Key
LPLHRXWGAXZZJU-WJDWOHSUSA-N
InChi Code
InChI=1S/C19H18N4OS/c24-18-16(11-14-12-22-17-15(14)7-4-9-20-17)25-19(23-18)21-10-8-13-5-2-1-3-6-13/h1-7,9,11-12,15,17,22H,8,10H2,(H,21,23,24)/b16-11-
SMILES Code
O=C(/C(S/1)=C/C2=CNC3N=CC=CC23)NC1=N/CCC4=CC=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
350.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Golla U, Ehudin MA, Annageldiyev C, Zeng Z, Bastihalli Tukaramrao D, Tarren
A, Date AA, Elcheva I, Berg A, Amin S, Loughran TP Jr, Kester M, Desai D, Dovat
S, Claxton D, Sharma A. DJ4 Targets the Rho-Associated Protein Kinase Pathway
and Attenuates Disease Progression in Preclinical Murine Models of Acute Myeloid
Leukemia. Cancers (Basel). 2021 Sep 29;13(19):4889. doi:
10.3390/cancers13194889. PMID: 34638385; PMCID: PMC8508452.
2: Abdul KM, Terada K, Gotoh T, Hafizur RM, Mori M. Characterization and
functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4. Cell
Stress Chaperones. 2002 Apr;7(2):156-66. doi:
10.1379/1466-1268(2002)007<0156:cafaoa>2.0.co;2. PMID: 12380683; PMCID:
PMC514813.
3: Kale VP, Hengst JA, Sharma AK, Golla U, Dovat S, Amin SG, Yun JK, Desai DH.
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective
Inhibitor of ROCK and MRCK Kinases. Pharmaceuticals (Basel). 2023 Jul
26;16(8):1060. doi: 10.3390/ph16081060. PMID: 37630974; PMCID: PMC10458458.
