Synonym
RS5517; RS 5517; RS-5517
IUPAC/Chemical Name
3-benzyl-5-chloro-N-(4-(hydroxymethyl)phenyl)-1H-indole-2-carboxamide
InChi Key
FHIRYPMBXVLHTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H19ClN2O2/c24-17-8-11-21-19(13-17)20(12-15-4-2-1-3-5-15)22(26-21)23(28)25-18-9-6-16(14-27)7-10-18/h1-11,13,26-27H,12,14H2,(H,25,28)
SMILES Code
O=C(C1=C(CC2=CC=CC=C2)C3=C(C=CC(Cl)=C3)N1)NC4=CC=C(CO)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
390.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zeng Y, Zhang L, Hu ZY, Yang QD, Liu BQ, Ma MM, Liu YH, Xu HW, Xia J, Du XP,
Hu ZP. [Association of single nucleotide polymorphisms of kallikrein 1 gene with
cerebral hemorrhage in Changsha Han Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za
Zhi. 2010 Jun;27(3):316-9. Chinese. doi:
10.3760/cma.j.issn.1003-9406.2010.0.017. PMID: 20533273.
2: Saponaro C, Sergio S, Coluccia A, De Luca M, La Regina G, Mologni L,
Famiglini V, Naccarato V, Bonetti D, Gautier C, Gianni S, Vergara D, Salzet M,
Fournier I, Bucci C, Silvestri R, Passerini CG, Maffia M, Coluccia AML.
β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer
cells: implications for a double-targeted therapy. Oncogene. 2018
Jun;37(24):3301-3316. doi: 10.1038/s41388-018-0170-y. Epub 2018 Mar 19. PMID:
29551770; PMCID: PMC6002344.
3: Zhao W, Wang L, Lu X, Yang W, Huang J, Chen S, Gu D. A coding polymorphism of
the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-
based association study in a Chinese Han population. J Hypertens. 2007
Sep;25(9):1821-7. doi: 10.1097/HJH.0b013e328244e119. PMID: 17762646.
4: Jiang S, Hsu YH, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Effects of
protein coding polymorphisms in the kallikrein 1 gene on baseline blood pressure
and antihypertensive response to irbesartan in Chinese hypertensive patients. J
Hum Hypertens. 2011 May;25(5):327-33. doi: 10.1038/jhh.2010.70. Epub 2010 Jul 8.
PMID: 20613781.
