T007-1 | colchicine-targeted covalent | MDgA | Microtubule Degradation Agent

MedKoo Cat#: 125024 | Name: T007-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T007-1 is a colchicine-targetedcovalentMDgA (Microtubule Degradation Agent)

Chemical Structure

T007-1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125024

Name: T007-1

CAS#: N/A

Chemical Formula: C26H20ClN3O4

Exact Mass: 473.1100

Molecular Weight: 473.91

Elemental Analysis: C, 65.90; H, 4.25; Cl, 7.48; N, 8.87; O, 13.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

T007-1; T007 1; T0071

IUPAC/Chemical Name

1-(2-chloro-5-nitrophenyl)-2-(2-((3-phenoxybenzyl)amino)pyridin-4-yl)ethan-1-one

InChi Key

ZTKNLWHRPMMNOE-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H20ClN3O4/c27-24-10-9-20(30(32)33)16-23(24)25(31)14-18-11-12-28-26(15-18)29-17-19-5-4-8-22(13-19)34-21-6-2-1-3-7-21/h1-13,15-16H,14,17H2,(H,28,29)

SMILES Code

ClC1=CC=C([N+]([O-])=O)C=C1C(CC2=CC(NCC3=CC=CC(OC4=CC=CC=C4)=C3)=NC=C2)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 473.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Yang J, Li Y, Yan W, Li W, Qiu Q, Ye H, Chen L. Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation. J Biol Chem. 2019 May 17;294(20):8161-8170. doi: 10.1074/jbc.RA118.006325. Epub 2019 Apr 2. PMID: 30940730; PMCID: PMC6527155.