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MedKoo Cat#: 124945 | Name: BMS-986172

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-986172 is a highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a L BMS-986172 showed on-target- and mechanism-based pharmacology. Moreover, its favorable pharmacokinetic (PK) profile and the lack of species variability in the glucuronidation potential resulted in a greater confidence level in the projection of a low dose for achieving targeted efficacious exposures in humans. Consistent with these projections.

Chemical Structure

BMS-986172
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124945

Name: BMS-986172

CAS#: N/A

Chemical Formula: C24H22F7N7O3

Exact Mass: 589.1700

Molecular Weight: 589.47

Elemental Analysis: C, 48.90; H, 3.76; F, 22.56; N, 16.63; O, 8.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMS-986172; BMS986172; BMS 986172;
IUPAC/Chemical Name
(S)-4-(1-(cyclopropylmethyl)-1H-pyrazol-3-yl)-6-(2-fluoro-4-(4,4,4-trifluorobutoxy)phenyl)-3-(5-oxo-4,5-dihydro-1H-tetrazol-1-yl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
InChi Key
VFFPVFKSCNJAMO-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H22F7N7O3/c25-17-10-14(41-9-1-7-23(26,27)28)4-5-16(17)22(24(29,30)31)11-15(18-6-8-37(34-18)12-13-2-3-13)19(20(39)32-22)38-21(40)33-35-36-38/h4-6,8,10,13H,1-3,7,9,11-12H2,(H,32,39)(H,33,36,40)
SMILES Code
FC1=C([C@@]2(C(F)(F)F)NC(C(N3C(NN=N3)=O)=C(C4=NN(CC5CC5)C=C4)C2)=O)C=CC(OCCCC(F)(F)F)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 589.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders Wei Meng, Robert Brigance, James Mignone, Lidet Negash, Guohua Zhao, Saleem Ahmad, Wei Wang, Fang Moore, Xiang-Yang Ye, Jung-Hui Sun, Arvind Mathur, Yi-Xin Li, Anthony Azzara, Zhengping Ma, Ching-Hsuen Chu, Mary Jane Cullen, Suzanne Rooney, Susan Harvey, Lisa Kopcho, Lynn Abell, Kevin O’Malley, William Keim, Elizabeth A. Dierks, Shu Chang, Kimberly A. Foster, David Harden, Marta Dabros, Vineet Goti, Claudia De Oliveira, Gopal Krishna, Mary Ann Pelleymounter, Jean Whaley, Jeffrey A. Robl, Dong Cheng, and Pratik Devasthale Journal of Medicinal Chemistry Article ASAP DOI: 10.1021/acs.jmedchem.3c01147