MedKoo Cat#: 124889 | Name: GNE-235

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GNE-235 is a PBRM1 inhibitor.

Chemical Structure

GNE-235
GNE-235
CAS#124889

Theoretical Analysis

MedKoo Cat#: 124889

Name: GNE-235

CAS#: 124889

Chemical Formula: C13H16N4O

Exact Mass: 244.1300

Molecular Weight: 244.30

Elemental Analysis: C, 63.91; H, 6.60; N, 22.93; O, 6.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GNE-235; GNE235; GNE 235
IUPAC/Chemical Name
(S)-6-(furan-2-yl)-4-(2-methylpyrrolidin-1-yl)pyridazin-3-amine
InChi Key
HDGYSKKTWNREMX-VIFPVBQESA-N
InChi Code
InChI=1S/C13H16N4O/c1-9-4-2-6-17(9)11-8-10(15-16-13(11)14)12-5-3-7-18-12/h3,5,7-9H,2,4,6H2,1H3,(H2,14,16)/t9-/m0/s1
SMILES Code
NC(N=N1)=C(N2[C@@H](C)CCC2)C=C1C3=CC=CO3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Cochran AG, Flynn M. GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. J Med Chem. 2023 Sep 13. doi: 10.1021/acs.jmedchem.3c01149. Epub ahead of print. PMID: 37702400.