ABX-196 | iNKT Agonist | CAS#1161877-58-2

MedKoo Cat#: 124881 | Name: ABX-196

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABX196, a Novel Enhancer of Cancer Immunotherapy, is iNKT Agonist.

Chemical Structure

ABX-196

CAS#1161877-58-2

Theoretical Analysis

MedKoo Cat#: 124881

Name: ABX-196

CAS#: 1161877-58-2

Chemical Formula: C50H98N2O9

Exact Mass: 870.7300

Molecular Weight: 871.34

Elemental Analysis: C, 68.92; H, 11.34; N, 3.22; O, 16.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ABX-196; ABX 196; ABX196

IUPAC/Chemical Name

N-((2S,3S,4R)-1-(((2S,3R,4S,5R,6R)-6-(acetamidomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxyoctadecan-2-yl)tetracosanamide

InChi Key

VITDDUXZOHEQMU-BYSUZVQFSA-N

InChi Code

InChI=1S/C50H98N2O9/c1-4-6-8-10-12-14-16-18-19-20-21-22-23-24-25-26-28-30-32-34-36-38-45(55)52-42(40-60-50-49(59)48(58)47(57)44(61-50)39-51-41(3)53)46(56)43(54)37-35-33-31-29-27-17-15-13-11-9-7-5-2/h42-44,46-50,54,56-59H,4-40H2,1-3H3,(H,51,53)(H,52,55)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1

SMILES Code

CCCCCCCCCCCCCCCCCCCCCCCC(N[C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)CO[C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CNC(C)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 871.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L, Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination. Vaccine. 2014 Oct 21;32(46):6138-45. doi: 10.1016/j.vaccine.2014.08.070. Epub 2014 Sep 13. PMID: 25218293; PMCID: PMC4233108. 2: Scherrer D, Barrett N, Teyton L, Pearce T, Nitcheu J, Pouletty P, Santo J, Ehrlich HJ. Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models. Mol Cancer Ther. 2022 Dec 2;21(12):1788-1797. doi: 10.1158/1535-7163.MCT-22-0183. PMID: 36198025; PMCID: PMC9716246.