Dazdotuftide is a novel, small synthetic molecule. It is a peptide conjugate comprised of tuftsin and phosphorylcholine that are covalently attached. The phosphorylcholine (PPC) moiety is based on a sequence from helminths’ secretory molecules which has been shown to be responsible for their immunoregulatory functions. Dazdotuftide and its components demonstrated in various autoimmune animal models and in vitro test systems its inhibitory effect on TLR-4 (inhibition of NfKb cascade), NRP-1 (inhibition of VEGF 165), and ACE2
MedKoo Cat#: 124808
Name: Dazdotuftide
CAS#: 2522933-44-2
Chemical Formula: C43H68N13O13P
Exact Mass: 1005.4800
Molecular Weight: 1006.07
Elemental Analysis: C, 51.34; H, 6.81; N, 18.10; O, 20.67; P, 3.08
The following data is based on the product molecular weight 1,006.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
