Synonym
Camonagrel; 105920-77-2; Camonagrelum
IUPAC/Chemical Name
5-(2-imidazol-1-ylethoxy)-2,3-dihydro-1H-indene-1-carboxylic acid
InChi Key
IRWWXLHSNMVHNY-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H16N2O3/c18-15(19)14-3-1-11-9-12(2-4-13(11)14)20-8-7-17-6-5-16-10-17/h2,4-6,9-10,14H,1,3,7-8H2,(H,18,19)
SMILES Code
O=C(C1CCC2=C1C=CC(OCCN3C=CN=C3)=C2)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
272.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Albet C, Pérez A, Rozman E, Sacristan A, Ortiz JA. Pharmacokinetics of
Camonagrel in experimental animal: rat, rabbit and dog. Eur J Drug Metab
Pharmacokinet. 1998 Apr-Jun;23(2):251-4. doi: 10.1007/BF03189347. PMID: 9725489.
2: Gryglewski RJ, Szczeklik A, Korbut R, Swies J, Musiał J, Krzanowski M, Maga
P. The mechanism of anti-thrombotic, thrombolytic and fibrinolytic actions of
camonagrel--a new thromboxane synthase inhibitor. Wien Klin Wochenschr.
1995;107(9):283-9. PMID: 7778318.
3: De La Cruz JP, Moreno A, Ruiz-Ruiz MI, García Campos J, Sánchez de la Cuesta
F. Effect of camonagrel, a selective thromboxane synthase inhibitor, on retinal
vascularization in experimental diabetes. Eur J Pharmacol. 1998 May
29;350(1):81-5. doi: 10.1016/s0014-2999(98)00233-7. PMID: 9683018.
4: Villalobos MA, De La Cruz JP, Escalante R, Arrebola MM, Guerrero A, Sánchez
de la Cuesta F. Effects of camonagrel, a selective inhibitor of platelet
thromboxane synthase, on the platelet-subendothelium interaction. Pharmacology.
2003 Sep;69(1):44-50. doi: 10.1159/000071266. PMID: 12886030.
5: Partyka L, Dembińska-Kieć A, Pankiewicz J, Dudek D, Hartwich J, Siedlecki A,
Pawlus E, Marquez-Perez M, Torres-Herrera J. An inhibitory effect of
camonagrel-a new thromboxane synthase inhibitor, on P-selectin-mediated
platelet/PMN adhesion. Platelets. 1996;7(3):169-72. doi:
10.3109/09537109609023576. PMID: 21043596.
