S17834 | pan-NOX inhibitor

MedKoo Cat#: 124753 | Name: S17834

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S17834 is a pan-NOX inhibitor.

Chemical Structure

S17834

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124753

Name: S17834

CAS#: N/A

Chemical Formula: C25H24O6

Exact Mass: 420.1600

Molecular Weight: 420.46

Elemental Analysis: C, 71.42; H, 5.75; O, 22.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

S17834; S-17834; S 17834

IUPAC/Chemical Name

6,8-diallyl-2-(2-allyl-3-hydroxy-4-methoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

InChi Key

UFZXTSPKPWLBPS-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H24O6/c1-5-8-15-14(11-12-19(30-4)23(15)28)20-13-18(26)21-24(29)16(9-6-2)22(27)17(10-7-3)25(21)31-20/h5-7,11-13,27-29H,1-3,8-10H2,4H3

SMILES Code

OC1=C(C(O)=C(C(C=C(C2=C(C(O)=C(OC)C=C2)CC=C)O3)=O)C3=C1CC=C)CC=C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cayatte AJ, Rupin A, Oliver-Krasinski J, Maitland K, Sansilvestri-Morel P, Boussard MF, Wierzbicki M, Verbeuren TJ, Cohen RA. S17834, a new inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase. Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1577-84. doi: 10.1161/hq1001.096723. PMID: 11597929. 2: Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation. 2012 Apr 10;125(14):1757-64, S1-6. doi: 10.1161/CIRCULATIONAHA.111.067801. Epub 2012 Mar 2. PMID: 22388319; PMCID: PMC3354628. 3: Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA. High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Sep;58(3):263-71. doi: 10.1097/FJC.0b013e3182239eb7. PMID: 21654327; PMCID: PMC3168693. 4: Williams HC, Griendling KK. NADPH oxidase inhibitors: new antihypertensive agents? J Cardiovasc Pharmacol. 2007 Jul;50(1):9-16. doi: 10.1097/FJC.0b013e318063e820. PMID: 17666910. 5: Schramm A, Matusik P, Osmenda G, Guzik TJ. Targeting NADPH oxidases in vascular pharmacology. Vascul Pharmacol. 2012 May-Jun;56(5-6):216-31. doi: 10.1016/j.vph.2012.02.012. Epub 2012 Mar 3. PMID: 22405985; PMCID: PMC3378316. 6: Jaulmes A, Sansilvestri-Morel P, Rolland-Valognes G, Bernhardt F, Gaertner R, Lockhart BP, Cordi A, Wierzbicki M, Rupin A, Verbeuren TJ. Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells. Thromb Res. 2009 Sep;124(4):439-46. doi: 10.1016/j.thromres.2009.05.018. Epub 2009 Jun 21. PMID: 19540572.