Synonym
BCPA; BCP A; BC PA
IUPAC/Chemical Name
(2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(2-chlorophenyl)acrylamide)
InChi Key
KHDKYKZKDQMAKP-PHEQNACWSA-N
InChi Code
InChI=1S/C22H22Cl2N2O2/c23-19-9-3-1-7-17(19)11-13-21(27)25-15-5-6-16-26-22(28)14-12-18-8-2-4-10-20(18)24/h1-4,7-14H,5-6,15-16H2,(H,25,27)(H,26,28)/b13-11+,14-12+
SMILES Code
O=C(NCCCCNC(/C=C/C1=C(Cl)C=CC=C1)=O)/C=C/C2=C(Cl)C=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
417.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cho E, Lee JK, Lee JY, Chen Z, Ahn SH, Kim ND, Kook MS, Min SH, Park BJ, Lee
TH. BCPA {N,N'-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]}
Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-
Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1. Int J Mol
Sci. 2018 Nov 1;19(11):3436. doi: 10.3390/ijms19113436. PMID: 30388885; PMCID:
PMC6275020.
2: Garcia EC, Anderson MS, Hagar JA, Cotter PA. Burkholderia BcpA mediates
biofilm formation independently of interbacterial contact-dependent growth
inhibition. Mol Microbiol. 2013 Sep;89(6):1213-25. doi: 10.1111/mmi.12339. Epub
2013 Aug 16. PMID: 23879629; PMCID: PMC3786370.
3: Budzik JM, Oh SY, Schneewind O. Cell wall anchor structure of BcpA pili in
Bacillus anthracis. J Biol Chem. 2008 Dec 26;283(52):36676-86. doi:
10.1074/jbc.M806796200. Epub 2008 Oct 21. PMID: 18940793; PMCID: PMC2605976.
4: Liang F, Senzaki H, Yin Z, Fan Y, Sughimoto K, Liu H. Transient hemodynamic
changes upon changing a BCPA into a TCPC in staged Fontan operation: a
computational model study. ScientificWorldJournal. 2013 Nov 10;2013:486815. doi:
10.1155/2013/486815. PMID: 24319371; PMCID: PMC3844169.
