MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 124725 | Name: Flufylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FLUFYLLINE, a theophylline derivative, has a long-lasting blood pressure lowering activity as well as remarkable serotonin- and histamine antagonism and broncholytic activity.

Chemical Structure

Flufylline
Flufylline
CAS#82190-91-8

Theoretical Analysis

MedKoo Cat#: 124725

Name: Flufylline

CAS#: 82190-91-8

Chemical Formula: C21H24FN5O3

Exact Mass: 413.1900

Molecular Weight: 413.45

Elemental Analysis: C, 61.01; H, 5.85; F, 4.60; N, 16.94; O, 11.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Flufylline; Flufyllin; 82190-91-8; Flufylline [INN]; Flufilina [Spanish];
IUPAC/Chemical Name
7-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1,3-dimethylpurine-2,6-dione
InChi Key
PMEYQPKJAPXGPS-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24FN5O3/c1-24-19-17(20(29)25(2)21(24)30)27(13-23-19)12-11-26-9-7-15(8-10-26)18(28)14-3-5-16(22)6-4-14/h3-6,13,15H,7-12H2,1-2H3
SMILES Code
O=C(N1C)N(C)C2=C(N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C=N2)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Korstanje C, Sprenkels R, Doods HN, Hugtenburg JG, Boddeke E, Batink HD, Thoolen MJ, Van Zwieten PA. Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin. J Pharm Pharmacol. 1986 May;38(5):374-9. doi: 10.1111/j.2042-7158.1986.tb04590.x. PMID: 2872314. 2: Thiele K, Jahn U, Geissmann F, Zirngibl L. Neue biologisch aktive Theophyllin-Derivate. Synthese und pharmakologische Eigenschaften von Flufyllin und Fluprofyllin [New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline]. Arzneimittelforschung. 1984;34(1):1-4. German. PMID: 6608355.