Synonym
IMMH-010; IMMH 010; IMMH010;
IUPAC/Chemical Name
isopropyl ((4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-(pyridin-3-ylmethoxy)cyclohexa-2,4-dien-1-yl)methyl)serinate maleate
InChi Key
DEQASHWAIDMMJN-BTJKTKAUSA-N
InChi Code
InChI=1S/C32H34BrClN2O5.C4H4O4/c1-21(2)41-32(38)28(18-37)36-17-25-14-27(34)30(15-29(25)39-19-22-8-7-13-35-16-22)40-20-24-11-6-12-26(31(24)33)23-9-4-3-5-10-23;5-3(6)1-2-4(7)8/h3-13,15-16,21,25,28,36-37H,14,17-20H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
ClC1=C(OCC2=C(Br)C(C3=CC=CC=C3)=CC=C2)C=C(OCC4=CN=CC=C4)C(CNC(C(OC(C)C)=O)CO)C1.[H]/C(C(O)=O)=C(C(O)=O)\[H]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
758.06
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jiang J, Zou X, Liu Y, Liu X, Dong K, Yao X, Feng Z, Chen X, Sheng L, Li Y.
Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active
Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid
Chromatography-Tandem Mass Spectrometry: Application to ADME Studies. Front
Pharmacol. 2021 Jun 21;12:677120. doi: 10.3389/fphar.2021.677120. PMID:
34234673; PMCID: PMC8256334.
2: Wang Y, Liu X, Zou X, Wang S, Luo L, Liu Y, Dong K, Yao X, Li Y, Chen X,
Sheng L. Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell
Death Ligand 1 Inhibitor Prodrug. Pharmaceutics. 2021 Apr 21;13(5):598. doi:
10.3390/pharmaceutics13050598. PMID: 33919384; PMCID: PMC8143347.
