AT-127 | nociceptin/orphanin FQ receptor | CAS#2099680-72-3

MedKoo Cat#: 124679 | Name: AT-127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AT-127 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist.

Chemical Structure

AT-127

CAS#2099680-72-3

Theoretical Analysis

MedKoo Cat#: 124679

Name: AT-127

CAS#: 2099680-72-3

Chemical Formula: C22H31N3O2

Exact Mass: 369.2400

Molecular Weight: 369.51

Elemental Analysis: C, 71.51; H, 8.46; N, 11.37; O, 8.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AT-127; AT 127; AT127

IUPAC/Chemical Name

(Z)-3-(hydroxyimino)-1-(1-((1s,4s)-4-isopropylcyclohexyl)piperidin-4-yl)indolin-2-one

InChi Key

KWBQOLLNTYZYQA-QCXOWIDRSA-N

InChi Code

InChI=1S/C22H31N3O2/c1-15(2)16-7-9-17(10-8-16)24-13-11-18(12-14-24)25-20-6-4-3-5-19(20)21(23-27)22(25)26/h3-6,15-18,27H,7-14H2,1-2H3/b23-21-/t16-,17+

SMILES Code

O=C1N(C2CCN([C@H]3CC[C@@H](C(C)C)CC3)CC2)C4=C(C=CC=C4)/C1=N/O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Denys IB, Gao J, Sutphen JC, Zaveri NT, Kapusta DR. Cardiovascular and renal effects of novel nonpeptide nociceptin opioid peptide receptor agonists. Br J Pharmacol. 2022 Jan;179(2):287-300. doi: 10.1111/bph.15717. Epub 2021 Dec 12. PMID: 34705263; PMCID: PMC8716424. 2: Ferrari F, Cerlesi MC, Malfacini D, Asth L, Gavioli EC, Journigan BV, Kamakolanu UG, Meyer ME, Yasuda D, Polgar WE, Rizzi A, Guerrini R, Ruzza C, Zaveri NT, Calo G. In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations. Eur J Pharmacol. 2016 Dec 15;793:1-13. doi: 10.1016/j.ejphar.2016.10.025. Epub 2016 Oct 22. PMID: 27780725; PMCID: PMC5555400.