MedKoo Cat#: 124668 | Name: Pirdonium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pirdonium is an antihistamine agent. It is the hydrophilic Histamine H1 receptor antagonist.

Chemical Structure

Pirdonium bromide
Pirdonium bromide
CAS#35620-67-8

Theoretical Analysis

MedKoo Cat#: 124668

Name: Pirdonium bromide

CAS#: 35620-67-8

Chemical Formula: C22H30BrNO

Exact Mass: 403.1500

Molecular Weight: 404.39

Elemental Analysis: C, 65.34; H, 7.48; Br, 19.76; N, 3.46; O, 3.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Pirdonium bromide; 35620-67-8; UNII-5123Q291S5; 5123Q291S5; Pirdonium bromide [INN]
IUPAC/Chemical Name
1,1-dimethyl-2-((phenyl(p-tolyl)methoxy)methyl)piperidin-1-ium bromide
InChi Key
DJJOASJXEODSJF-UHFFFAOYSA-M
InChi Code
InChI=1S/C22H30NO.BrH/c1-18-12-14-20(15-13-18)22(19-9-5-4-6-10-19)24-17-21-11-7-8-16-23(21,2)3;/h4-6,9-10,12-15,21-22H,7-8,11,16-17H2,1-3H3;1H/q+1;/p-1
SMILES Code
CC1=CC=C(C=C1)C(C2=CC=CC=C2)OCC3CCCC[N+]3(C)C.[Br-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hishinuma S, Komazaki H, Tsukamoto H, Hatahara H, Fukui H, Shoji M. Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells. J Neurochem. 2018 Jan;144(1):68-80. doi: 10.1111/jnc.14245. Epub 2017 Nov 21. PMID: 29063596. 2: Hishinuma S, Komazaki H, Fukui H, Shoji M. Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells. J Neurochem. 2010 May;113(4):990-1001. doi: 10.1111/j.1471-4159.2010.06669.x. Epub 2010 Mar 4. PMID: 20236220. 3: Hishinuma S, Young JM. Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation. Br J Pharmacol. 1995 Nov;116(6):2715-23. doi: 10.1111/j.1476-5381.1995.tb17232.x. PMID: 8590995; PMCID: PMC1909113. 4: Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol. 2005 Oct;146(4):612-24. doi: 10.1038/sj.bjp.0706337. PMID: 16086035; PMCID: PMC1751180. 5: Hishinuma S, Naiki A, Tsuga H, Young JM. Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells. J Neurochem. 1998 Dec;71(6):2626-33. doi: 10.1046/j.1471-4159.1998.71062626.x. PMID: 9832164.