Bnota-prgd2 Ga-68 | radiopharmaceutical agent | CAS#1345968-02-6

MedKoo Cat#: 124667 | Name: Bnota-prgd2 Ga-68

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gallium Ga 68-labeled BNOTA-PRGD2 is a radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid dimer (PRGD2) labeled with gallium Ga 68, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET) or single photon emission computed tomography (SPECT).

Chemical Structure

Bnota-prgd2 Ga-68

CAS#1345968-02-6

Theoretical Analysis

MedKoo Cat#: 124667

Name: Bnota-prgd2 Ga-68

CAS#: 1345968-02-6

Chemical Formula: C87H125GaN24O28S

Exact Mass: 2054.8100

Molecular Weight: 2056.88

Elemental Analysis: C, 50.80; H, 6.13; Ga, 3.39; N, 16.34; O, 21.78; S, 1.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

(68Ga)Nota-prgd2; (68Ga)Bnota-prgd2; 68Ga-Bnota-prgd 2; 68Ga-Prgd2; Bnota-prgd2 Ga-68; GALLIUM GA 68-LABELED BNOTA-PRGD2

IUPAC/Chemical Name

gallium 2,2',2''-(2-(4-(3-(13-((4-(11-(carboxymethyl)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)carbamoyl)-21-(11-(carboxymethyl)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)-11,16-dioxo-3,6,9-trioxa-12,17-diazahenicosyl)thioureido)benzyl)-1,4,7-triazonane-1,4,7-triyl)triacetate

InChi Key

REZUNGDMWFMGQF-UHFFFAOYSA-K

InChi Code

InChI=1S/C87H128N24O28S.Ga/c88-85(89)94-27-5-9-58-77(129)97-44-68(115)101-65(42-71(118)119)83(135)107-63(40-52-13-19-56(112)20-14-52)81(133)105-60(79(131)103-58)7-1-3-25-92-67(114)24-23-62(100-70(117)50-139-38-37-138-36-35-137-34-29-96-87(140)99-54-17-11-51(12-18-54)39-55-46-110(48-74(124)125)31-30-109(47-73(122)123)32-33-111(55)49-75(126)127)76(128)93-26-4-2-8-61-80(132)104-59(10-6-28-95-86(90)91)78(130)98-45-69(116)102-66(43-72(120)121)84(136)108-64(82(134)106-61)41-53-15-21-57(113)22-16-53;/h11-22,55,58-66,112-113H,1-10,23-50H2,(H,92,114)(H,93,128)(H,97,129)(H,98,130)(H,100,117)(H,101,115)(H,102,116)(H,103,131)(H,104,132)(H,105,133)(H,106,134)(H,107,135)(H,108,136)(H,118,119)(H,120,121)(H,122,123)(H,124,125)(H,126,127)(H4,88,89,94)(H4,90,91,95)(H2,96,99,140);/q;+3/p-3

SMILES Code

C1CN(CC(N(CCN1CC(=O)[O-])CC(=O)[O-])CC2=CC=C(C=C2)NC(=S)NCCOCCOCCOCC(=O)NC(CCC(=O)NCCCCC3C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N3)CC4=CC=C(C=C4)O)CC(=O)O)CCCNC(=N)N)C(=O)NCCCCC5C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N5)CC6=CC=C(C=C6)O)CC(=O)O)CCCNC(=N)N)CC(=O)[O-].[Ga+3]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,056.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li D, Zhang J, Ji N, Zhao X, Zheng K, Qiao Z, Li F, Lang L, Iagaru A, Niu G, Zhu Z, Chen X. Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma. Clin Nucl Med. 2018 Sep;43(9):648-654. doi: 10.1097/RLU.0000000000002233. PMID: 30052597. 2: Zheng K, Liang N, Zhang J, Lang L, Zhang W, Li S, Zhao J, Niu G, Li F, Zhu Z, Chen X. 68Ga-NOTA-PRGD2 PET/CT for Integrin Imaging in Patients with Lung Cancer. J Nucl Med. 2015 Dec;56(12):1823-7. doi: 10.2967/jnumed.115.160648. Epub 2015 Oct 1. PMID: 26429958; PMCID: PMC5223097. 3: Li D, Zhao X, Zhang L, Li F, Ji N, Gao Z, Wang J, Kang P, Liu Z, Shi J, Chen X, Zhu Z. (68)Ga-PRGD2 PET/CT in the evaluation of Glioma: a prospective study. Mol Pharm. 2014 Nov 3;11(11):3923-9. doi: 10.1021/mp5003224. Epub 2014 Aug 11. PMID: 25093246; PMCID: PMC4224544.